Whole-home air cleaners mount in the return duct or at the air handler, so all the air the blower moves passes through them on its way back to the coil. That's the advantage over a portable unit in one room. When the system runs, the whole house is being treated.
The category is broad, and the products in it work in very different ways. Some are simply bigger, better filters. Some use an electrical charge to collect particles. Some use ultraviolet light, catalysts or charged ions to treat the air and the surfaces it touches. Carbon media go after odors and gases rather than particles. A comparison only makes sense type by type.
Air scrubbers
In home HVAC, "air scrubber" usually means a unit installed in the supply or return duct that shines a UV lamp on a surface coated with a catalyst, sometimes paired with an ionizer. As air passes through, the unit is designed to break down odor-causing gases and treat surfaces the air reaches. It isn't a filter. It does little for dust, and it does nothing for humidity, so it works alongside a good filter rather than in place of one.
An air scrubber makes the most sense when there is a specific target, such as lingering cooking or pet odors, in a house where moisture and the coil have already been checked. Before choosing one, ask for independent test data, confirm it is validated for zero ozone, and know when the lamp and catalyst cell need replacing. A lamp and cell past their service life keep running without doing much.
Particles, odors and gases
For particles like dust, pollen, pet dander and smoke, the most dependable upgrade is usually better filtration: a deep media cabinet that holds a high-rated filter without choking airflow. It's simple, the evidence behind it is strong, and the upkeep is a filter change.
For odors, carbon is the plain option. It adsorbs gases until it fills up, and then it gets replaced.
Products that claim to treat germs or chemicals in the air deserve more questions. Ask what was tested, by whom and at what airflow, and whether the device produces ozone. EPA advises against adding ozone to indoor air, and some ionizers and older electronic designs create it.
Fix the cause first
A lot of "air quality" complaints have causes an air cleaner won't touch. Dust that comes back days after cleaning can point to leaking return ducts pulling in attic air. A musty smell usually traces back to moisture: a dirty coil, a drain pan that doesn't empty, or a house that stays too humid. We check those first. Then, if an air cleaner or air scrubber would add something, we'll say which type and why.